Risk of developing sleep disorders and psychologic comorbidity in children with inflammatory skin diseases—A population-based study
Caroline Mann, Andreas Wollenberg, Sascha Ständer, Petra Staubach, Diamant Thaçi, Henner Zirpel
Abstract
BACKGROUND: Inflammatory skin diseases such as atopic dermatitis (AD), psoriasis, and urticaria are associated with impaired mental health and sleep. In children the risk of developing these comorbidities is still poorly evaluated. METHODS: Retrospective data analysis of a US Collaborative Network including children of 55 health care providers was performed. Data from electronic health records of patients with a diagnosis of either AD, psoriasis, or urticaria, as well as a control cohort were retrieved in an anonymized batch format and propensity score matched. RESULTS: Children with psoriasis had a 3.2-fold higher risk of hypersomnia, 2.1-fold higher risk of sleep apnea, 1.8-fold higher risk of fatigue, and 1.9-fold higher risk of depression. Children with urticaria (acute or chronic) and AD had a 1.7-fold higher risk of sleep disorders, 1.6-fold higher risk of anxiety disorders, and 1.4-fold higher risk of insomnia. AD children had a 1.5-fold higher risk of anxiety disorders. LIMITATIONS: Electronic health insurance data are not subject to random sampling of the general population and potential misdiagnosis is possible. CONCLUSIONS: Children with inflammatory skin diseases were at a higher risk of sleep psychological disorders. Thus, regularly performed screenings and appropriate treatment initiation might potentially prevent mental and physical health consequences and secure improved life quality.