Stereoselective coronas regulate the fate of chiral gold nanoparticles <i>in vivo</i>
Didar Baimanov, Liming Wang, Ke Liu, Mengmeng Pan, Rui Cai, Hao Yuan, Wanxia Huang, Qingxi Yuan, Yunlong Zhou, Chunying Chen, Yuliang Zhao
Abstract
. We observed that these stereoselective behaviors were correlated to subgroups of the corona composition that could bind to low-density lipoprotein receptors. Therefore, this study reveals how chirality-specific protein compositions selectively recognize and interact with cell receptors for chirality-mediated tissue accumulation. This study will deepen our understanding of how chiral nanoparticles/nanomedicine/nanocarriers interact with biological systems to guide the efficient fabrication of target nanomedicines.
Topics & Concepts
Chirality (physics)BiodistributionColloidal goldNanomedicineIn vivoNanocarriersBiophysicsNanoparticleChemistryNanotechnologyMaterials scienceIn vitroBiochemistryBiologyPhysicsQuantum mechanicsChiral symmetry breakingNambu–Jona-Lasinio modelQuarkBiotechnologyNanoparticle-Based Drug DeliveryDrug Transport and Resistance MechanismsGold and Silver Nanoparticles Synthesis and Applications