Differences in vasomotor function of mesenteric arteries between Ossabaw minipigs with predisposition to metabolic syndrome and Göttingen minipigs
Chantal Eickelmann, Helmut Raphael Lieder, Michael Sturek, Gerd Heusch, Petra Kleinbongard
Abstract
Animal models with a predisposition to metabolic syndrome and atherosclerosis are attracting growing interest for translational research, as they may better mimic the variability of patients with cardiovascular disease. In Ossabaw minipigs, with a polygenic predisposition to metabolic syndrome, but without the diseased phenotype, vasoconstriction is more and vasodilation is less pronounced in mesenteric arteries than in Göttingen minipigs. Ossabaw minipigs may be a more suitable model of human cardiovascular disease.
Topics & Concepts
VasoconstrictionInternal medicineVasodilationVasomotorEndocrinologyMyographMedicineMesenteric arteriesNorepinephrineEndotheliumCardiologyArteryDopamineXenotransplantation and immune responseAdipose Tissue and MetabolismPancreatic function and diabetes