Litcius/Paper detail

Reducing affinity as a strategy to boost immunomodulatory antibody agonism

Xiaojie Yu, Christian M. Orr, H.T. Claude Chan, Sonya James, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Kerry L. Cox, Jonathan W. Essex, Ivo Tews, Martin J. Glennie, Mark S. Cragg

2023Nature116 citationsDOIOpen Access PDF

Topics & Concepts

Monoclonal antibodyAntibodyReceptorAffinity maturationBiologyAgonistCell biologyChemistryImmunologyBiochemistryMonoclonal and Polyclonal Antibodies ResearchCAR-T cell therapy researchT-cell and B-cell Immunology