“On-water” defluorinative cyclization of trifluoromethyl enones with phosphine oxides: synthesis of polysubstituted furans
Man-Hang Feng, Shu‐Ji Gao, Xiao-Ying Li, Mengtao Ma, Zhi‐Liang Shen, Xue‐Qiang Chu
Abstract
A defluorinative cyclization of readily available trifluoromethyl enones with phosphine oxides for the synthesis of polysubstituted furans is developed in a pure water solution.
Topics & Concepts
ChemistryTrifluoromethylPhosphinePhosphine oxideOrganic chemistryMedicinal chemistryCatalysisAlkylFluorine in Organic ChemistryCyclopropane Reaction MechanismsAsymmetric Synthesis and Catalysis