Mitochondrial DNA enables AIM2 inflammasome activation and hepatocyte pyroptosis in nonalcoholic fatty liver disease
Lu Xu, Jingyang Zhou, Jinhui Che, Haihong Wang, Weizhong Yang, Wuyuan Zhou, Hongying Zhao
Abstract
Mitochondria damage exacerbates NAFLD through trigerring AIM2 inflammasome activation and hepatocyte pyroptosis. This study provides novel insights into the underlying mechanisms of mitochondrial DNA synthesis in NAFLD and also suggests potential therapeutic targets for the treatment of NAFLD.
Topics & Concepts
PyroptosisInflammasomeAIM2Nonalcoholic fatty liver diseaseHepatocyteFatty liverMitochondrionChemistryBiologyCell biologyMedicineDiseaseInflammationBiochemistryImmunologyInternal medicineIn vitroLiver Disease Diagnosis and TreatmentInflammasome and immune disordersDiet, Metabolism, and Disease