Saffron extract (Safr'Inside™) improves anxiety related behaviour in a mouse model of low-grade inflammation through the modulation of the microbiota and gut derived metabolites
Matthew G. Pontifex, Emily Connell, Gwénaëlle Le Gall, Line Pourtau, David Gaudout, Cristina Angeloni, Lorenzo Zallocco, Maurizio Ronci, Laura Giusti, Michael Müller, David Vauzour
Abstract
abundance negatively correlated with the neurotoxic metabolite dimethylamine which was reduced in saffron supplemented animals. Brain proteomic analysis highlighted several significantly altered proteins including ketimine reductase mu-crystallin which also correlated with dimethylamine concentration. Both dimethylamine and ketimine reductase mu-crystallin were associated with OF performance. This may be indicative of a novel interaction across the gut-brain axis which contributes to anxiety-related disorders.
Topics & Concepts
InflammationGut floraAnxietyModulation (music)BiologyPsychologyImmunologyPsychiatryPhysicsAcousticsSaffron Plant Research StudiesSleep and Wakefulness ResearchDietary Effects on Health