Therapeutic potential of targeting regulatory mechanisms of hepatic stellate cell activation in liver fibrosis
Kaveh Baghaei
Abstract
Hepatic fibrosis is a manifestation of different etiologies of liver disease with the involvement of multiple mediators in complex network interactions. Activated hepatic stellate cells (aHSCs) are the central driver of hepatic fibrosis, given their potential to induce connective tissue formation and extracellular matrix (ECM) protein accumulation. Therefore, identifying the cellular and molecular pathways involved in the activation of HSCs is crucial in gaining mechanistic and therapeutic perspectives to more effectively target the disease. In addition to a comprehensive summary of our current understanding of the role of HSCs in liver fibrosis, we also discuss here the proposed therapeutic strategies based on targeting HSCs.
Topics & Concepts
Hepatic stellate cellExtracellular matrixHepatic fibrosisFibrosisLiver fibrosisCancer researchBiologyMedicineCell biologyPathologyLiver physiology and pathologyLiver Disease Diagnosis and TreatmentLiver Diseases and Immunity