Phase-lagged tACS between executive and default mode networks modulates working memory
Jeehye Seo, Dongha Lee, Dimitrios Pantazis, Byoung‐Kyong Min
Abstract
Transcranial alternating current stimulation (tACS) is an efficient neuromodulation technique to enhance cognitive function in a non-invasive manner. Using functional magnetic resonance imaging, we investigated whether a cross-frequency coupled tACS protocol with a phase lag (45 and 180 degrees) between the central executive and the default mode networks modulated working-memory performance. We found tACS-phase-dependent modulation of task performance reflected in hippocampal activation and task-related functional connectivity. Our observations provide a neurophysiological basis for neuromodulation and a feasible non-invasive approach to selectively stimulate a task-relevant deep brain structure. Overall, our study highlights the potential of tACS as a powerful tool for enhancing cognitive function and sheds light on the underlying mechanisms of this technique.