A Review of Prostanoid Receptors: Expression, Characterization, Regulation, and Mechanism of Action
Roger G. Biringer
Abstract
Prostaglandin signaling controls a wide range of biological processes from blood pressure homeostasis to inflammation and resolution thereof to the perception of pain to cell survival. Disruption of normal prostanoid signaling is implicated in numerous disease states. Prostaglandin signaling is facilitated by G-protein-coupled, prostanoid-specific receptors and the array of associated G-proteins. This review focuses on the expression, characterization, regulation, and mechanism of action of prostanoid receptors with particular emphasis on human isoforms.
Topics & Concepts
ProstanoidReceptorProstaglandinProstaglandin E2 receptorSignal transductionInflammationCell biologyG protein-coupled receptorHomeostasisMedicineBiologyImmunologyEndocrinologyInternal medicineAgonistInflammatory mediators and NSAID effectsEicosanoids and Hypertension PharmacologyEstrogen and related hormone effects