Efficacy of CTLA-4 checkpoint therapy is dependent on IL-21 signaling to mediate cytotoxic reprogramming of PD-1+CD8+ T cells

Zhen Zhang, Marlene Langenbach, Sagar Sagar, Viktor Fetsch, Jonas Stritzker, Elizabeth Severa, Ke Meng, Frances Winkler, Nisha Rana, Katharina Zoldan, Ira Godbole, Sabrina Solis, Jeffrey S. Weber, David Rafei‐Shamsabadi, Saskia Lehr, R. Diehl, Ana C Venhoff, Reinhard Voll, Nico Buettner, Christoph Neumann‐Haefelin, Tobias Boettler, Maike Hofmann, Melanie Boerries, Frank Meiß, Robert Zeiser, Robert Thimme, Ramin S. Herati, Bertram Bengsch