Lipid-Coated Hybrid Nanoparticles for Enhanced Bacterial Biofilm Penetration and Antibiofilm Efficacy
Hiang Wee Lee, Sharad Kharel, Say Chye Joachim Loo
Abstract
USA300 when compared against Free-Van and Van-PLGANPs. When used to treat USA300 biofilms, Van-LCHNPs eradicated up to 99.99% of the underlying biofilm cells, an effect which was not observed for Free-Van and Van-PLGANPs. Finally, we showed that by possessing a robust DOTAP shell, LCHNPs were able to penetrate deeply into the biofilms.
Topics & Concepts
BiofilmNanoparticlePenetration (warfare)NanotechnologyMaterials scienceChemistryChemical engineeringBacteriaBiologyGeneticsOperations researchEngineeringBacterial biofilms and quorum sensingAntimicrobial Peptides and ActivitiesAntimicrobial agents and applications