Asperosin A, a [4 + 2] Diels–Alder cycloaddition polyketide dimer from<i>Aspergillus rugulosa</i>with immunosuppressive activity
Yuben Qiao, Xiaosheng Tan, Qianqian Xu, Zijun Zhang, Qiaoxin Xu, Tao Li, Junjun Liu, Hucheng Zhu, Chunmei Chen, Ying Ye, Yuanyuan Lu, Gang Chen, Changxing Qi, Yonghui Zhang
Abstract
A novel homologous polyketide dimer, asperosin A (1), constructed with a unique hetero-bicycle 6/5 core skeleton featuring four continuous quaternary carbons, was isolated from a solid culture of the fungus Aspergillus rugulosa .
Topics & Concepts
ChemistryPolyketideDimerCycloadditionStereochemistryAspergillusFungusBotanyOrganic chemistryBiologyBiosynthesisEnzymeCatalysisMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsFungal Biology and Applications