Neuroprotective effects of probiotics on anxiety- and depression-like disorders in stressed mice by modulating tryptophan metabolism and the gut microbiota
Longgang Jia, Ling Xiao, Yao Fu, Zhen Shao, Zhaoxuan Jing, Jiahu Yuan, Yufeng Xie, Jun Guo, Yanping Wang, Weitao Geng
Abstract
compared to those in CUMS mice. Our work demonstrates that D-9 alleviated anxiety- and depression-like disorders in CUMS mice by modulating tryptophan metabolism and the gut microbiota. These findings provide an innovative strategy for the intervention and treatment of depressive disorders.
Topics & Concepts
NeuroprotectionDepression (economics)AnxietyGut–brain axisGut floraTryptophan MetabolismNeuroscienceTryptophanBiologyMedicinePharmacologyImmunologyPsychiatryBiochemistryAmino acidMacroeconomicsEconomicsGABA and Rice ResearchTryptophan and brain disordersGut microbiota and health