Fabrication of yeast β-glucan/sodium alginate/γ-polyglutamic acid composite particles for hemostasis and wound healing
Qinglin Zou, Hongdong Duan, Shimin Fang, Wenlong Sheng, Xiaobin Li, Rostyslav Stoika, Nataliya Finiuk, Rostyslav Panchuk, Kechun Liu, Lizhen Wang
Abstract
study revealed that the particles exhibited a low BCI value, low hemolysis ratio, and good cytocompatibility against L929 cells. The APGG particles could quickly stop bleeding in a mouse liver injury model and exhibited better hemostatic ability than the commercially available product Celox. Furthermore, the APGG particles could accelerate the healing of non-infected wounds, and the expression levels of CD31, α-SMA, and VEGF related to angiogenesis were significantly enhanced.
Topics & Concepts
Polyglutamic acidHemostasisChemistryWound healingYeastGlucanComposite numberBeta-glucanSodium alginateBiochemistrySodiumMicrobiologyMedicineImmunologyMaterials scienceBiologySurgeryComposite materialOrganic chemistryBiopolymer Synthesis and Applicationsbiodegradable polymer synthesis and propertiesElectrospun Nanofibers in Biomedical Applications