Au Nanorods Activate Zn<sup>2+</sup>/Ag<sup>+</sup> Mediated Anti-inflammatory for Enhanced Methicillin-Resistant Wound Repair via Bionic Claw Microneedles
Zheng Wang, Hui Shen, Yuanfang Cheng, Litao Liu, Jiangwei Sun, Zhaoyou Chu, Wanni Wang, Haisheng Qian
Abstract
Wound infections caused by methicillin-resistant Staphylococcus aureus (MRSA) have attracted wide attention owing to acidic biofilms and the alkaline wound microenvironment, which result in hindering wound healing. In this work, we prepared an acid–base responsive bionic claw microneedle (MN) loaded with Au@ZnO/Ag (AZA) core–shell nanoparticles, which shows excellent photothermal transition and antibacterial activity. In the acidic medium of the biofilm, 97.98% of bacteria were successfully eradicated under mild thermal conditions (≤40 °C). In the alkaline wound microenvironment, inflammatory cytokines were inhibited by Ag + . Vascular endothelial growth factor expression was promoted by trace Zn 2+, and the wound healing rate increased by up to 24.02% compared to the control group. The bionic claw MN loaded with AZA effectively combines the benefits of low-temperature acidic sterilization and alkaline anti-inflammatory activity. The promotion of MRSA infected wound healing through the synergistic effect of released Zn 2+ /Ag + and the mild thermal impact showcases new avenues for clinical treatment.