S100A proteins show a spatial distribution of inflammation associated with the glioblastoma microenvironment architecture
Blanca Cómitre-Mariano, Berta Segura‐Collar, Gabriel Velilla-Alonso, R. Contreras, Aurelio Hernandez-Lain, Manuel Valiente, Juan Manuel Sepúlveda-Sánchez, Stephen Marcus, Guillermo García-Posadas, Luis Jiménez‐Roldán, Ángel Pérez‐Núñez, Ricardo Gargini
Abstract
Our findings define different functions for S100A9, A11 and A13 proteins that are associated with the architecture of the glioblastoma microenvironment and define its progression. Moreover, these alterations can be reversed by the RAGE inhibitor, Azeliragon which is in a phase I/II clinical trial NCT05635734.
Topics & Concepts
GlioblastomaInflammationDistribution (mathematics)Tumor microenvironmentCancer researchComputational biologyNeuroscienceMedicineBiologyImmunologyTumor cellsMathematicsMathematical analysisS100 Proteins and AnnexinsCell Adhesion Molecules ResearchClusterin in disease pathology