Amelioration of ulcerative colitis <i>via</i> inflammatory regulation by macrophage-biomimetic nanomedicine
Tianlei Sun, Cheryl H. T. Kwong, Gao Cheng, Jianwen Wei, Ludan Yue, Jianxiang Zhang, Richard Dequan Ye, Ruibing Wang
Abstract
This macrophage-biomimetic nanomedicine leverages the inflammatory tropism and inflammatory cytokine sequestration effects of macrophage membrane for targeted delivery and local inflammation suppression, the ROS-responsiveness of β-cyclodextrin-based matrix for specific payload release, and the macrophage-polarizing effect of rosiglitazone for inflammatory regulation, thereby exhibiting considerable therapeutic efficacy against UC in mice. This study offers important new insights on the design and development of biomimetic nanomaterials for inflammation regulations.
Topics & Concepts
Ulcerative colitisNanomedicineMacrophageInflammatory Bowel DiseasesInflammationMedicineChemistryNanotechnologyImmunologyPathologyMaterials scienceNanoparticleBiochemistryDiseaseIn vitroNanoparticle-Based Drug DeliveryImmune cells in cancerInflammatory Bowel Disease