Design, synthesis, and aldose reductase inhibition assessment of novel Quinazolin-4(3H)-one derivatives with 4-Bromo-2-Fluorobenzene functionality
Pelin Tokalı, Yeliz Demir, Furkan Çakır, Halil Şenol, Feyzi Sinan Tokalı
Topics & Concepts
ChemistryPharmacologyAldose reductaseADMEAldose reductase inhibitorPharmacokineticsAldehyde ReductasePolar surface areaStereochemistryLead compoundBiochemistryIn vitroEnzymeOrganic chemistryMoleculeMedicineAldose Reductase and TaurineQuinazolinone synthesis and applicationsPhenothiazines and Benzothiazines Synthesis and Activities