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Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths

Mariela Cortés-López, Paulina Chamely, Allegra G. Hawkins, Robert Stanley, Ariel D. Swett, Saravanan Ganesan, Tarek H. Mouhieddine, Xiaoguang Dai, Lloyd Kluegel, Celine Chen, Kiran Batta, Nili Furer, Rahul S. Vedula, John Beaulaurier, Alexander Drong, Scott E. Hickey, Neville Dusaj, Gavriel Mullokandov, Adam M. Stasiw, Jiayu Su, Ronan Chaligné, Sissel Juul, Eoghan Harrington, David A. Knowles, Catherine Potenski, Daniel H. Wiseman, Amos Tanay, Liran I. Shlush, R. Coleman Lindsley, Irene M. Ghobrial, Justin Taylor, Omar Abdel‐Wahab, Federico Gaiti, Dan A. Landau

2023Cell stem cell62 citationsDOIOpen Access PDF

Topics & Concepts

BiologyOmicsHaematopoiesisCellAlternative splicingComputational biologyCell typeRNA splicingCell biologyHematopoietic cellGeneticsBioinformaticsStem cellGeneRNAMessenger RNASingle-cell and spatial transcriptomicsCancer Genomics and DiagnosticsRNA Research and Splicing
Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths | Litcius