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A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan

Manish Chamoli, Anand Rane, Anna Foulger, Shankar J. Chinta, Azar Asadi Shahmirzadi, Caroline Kumsta, Dhanya K. Nambiar, David Hall, Angelina Holcom, Suzanne Angeli, Minna Schmidt, Sharon J. Pitteri, Malene Hansen, Gordon J. Lithgow, Julie K. Andersen

2023Nature Aging36 citationsDOIOpen Access PDF

Topics & Concepts

MitophagyTFEBAutophagyBiologyCell biologyNuclear receptorRegulatorTranscription factorCaenorhabditis elegansMitochondrionGeneticsGeneApoptosisGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and TherapyGenomics, phytochemicals, and oxidative stress
A drug-like molecule engages nuclear hormone receptor DAF-12/FXR to regulate mitophagy and extend lifespan | Litcius