A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer
Jing Zhang, Ningning Wang, Qian Li, Yaxin Zhou, Yuxia Luan
Abstract
A two-pronged concept combining photodynamic therapy (PDT) and epithelial-mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to combat basal-like breast cancer (BLBC) metastasis. Based on PDT-mediated tumor killing and epalrestat (Epa)-mediated EMT blockade, as-prepared Ce6/Epa nanoparticles prevented BLBC metastasis effectively in vivo, providing a very promising two-pronged strategy against BLBC metastasis.
Topics & Concepts
Photodynamic therapyBreast cancerBreast cancer metastasisMetastasisBasal (medicine)Epithelial–mesenchymal transitionCancer researchCancer metastasisBlockadeMedicineCancerOncologyChemistryInternal medicineReceptorInsulinOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesCancer Cells and Metastasis