Combining Colistin and Fluconazole Synergistically Increases Fungal Membrane Permeability and Antifungal Cidality
Maayan Bibi, Sarah E. Murphy, Raphael I. Benhamou, Alex Rosenberg, Adi Ulman, Tihana Bicanic, Micha Fridman, Judith Berman
Abstract
, l-α-phosphatidylinositol, l-α-phosphatidyl-l-serine, and l-α-phosphatidylethanolamine) that are enriched in the membranes of ergosterol-depleted cells. These results support the idea that colistin binds to fungal membrane lipids and permeabilizes fungal cells in a manner that depends upon the degree of ergosterol depletion.
Topics & Concepts
FluconazoleColistinMicrobiologyBiologyMembrane permeabilityErgosterolCeruleninPharmacologyAntimicrobialAntifungalBiochemistryMembraneFatty acid synthaseFatty acidAntibiotic Resistance in BacteriaAntifungal resistance and susceptibilityPlant-Microbe Interactions and Immunity