NOTCH4 maintains quiescent mesenchymal-like breast cancer stem cells via transcriptionally activating SLUG and GAS1 in triple-negative breast cancer
Lei Zhou, Dong Wang, Dandan Sheng, Jiahui Xu, Weilong Chen, Yuanyuan Qin, Ruikai Du, Xiaoli Yang, Xue‐Yan He, Ni Xie, Suling Liu, Lixing Zhang
Abstract
Our findings reveal that the NOTCH4-SLUG-GAS1 circuit serves as a potential target for tumor intervention by overcoming stemness of ML-BCSCs and by conquering the lethal chemoresistance and metastasis of TNBC.
Topics & Concepts
SlugTriple-negative breast cancerCancer researchBiologyCD44Gene knockdownCancer stem cellChromatin immunoprecipitationBreast cancerMesenchymal stem cellCancerStem cellMolecular biologyCell biologyCell cultureCellPromoterGene expressionGeneGeneticsCancer Cells and MetastasisCancer-related molecular mechanisms researchRNA modifications and cancer