Tetra-(<i>p</i>-tolyl)antimony(III)-Containing Heteropolytungstates, [{(<i>p</i>-tolyl)Sb<sup>III</sup>}<sub>4</sub>(<i>A</i>-α-XW<sub>9</sub>O<sub>34</sub>)<sub>2</sub>]<sup><i>n</i>−</sup> (X = P, As, or Ge): Synthesis, Structure, and Study of Antibacterial and Antitumor Activity
Tian Ma, Peng Yang, Inga Dammann, Zhengguo Lin, Ali S. Mougharbel, Ming‐Xing Li, Florin Adǎscǎliţei, Raluca Mitea, Cristian Silvestru, Candice Thorstenson, Matthias S. Ullrich, Klaudia Cseh, Michael A. Jakupec, Bernhard K. Keppler, Manuela Donalisio, Roberta Cavalli, David Lembo, Ulrich Kortz
Abstract
We have synthesized and structurally characterized three tetra-(p-tolyl)antimony(III)-containing heteropolytungstates, [{(p-tolyl)SbIII}4(A-α-XW9O34)2]n− [X = PV (1-P), AsV (1-As), or GeIV (1-Ge)], in aqueous solution using conventional, one-pot procedures. The polyanions 1-P, 1-As, and 1-Ge were fully characterized in the solid state and in solution and were shown to be soluble and stable in aqueous medium at pH 7. Biological studies demonstrated that all three polyanions possess significant antibacterial and antitumor activities. The minimum inhibitory concentrations of 1-P, 1-As, and 1-Ge were determined against four kinds of bacteria, including the two pathogenic bacteria strains, Vibrio parahaemolyticus and Vibrio vulnificus. The three novel polyanions also showed high cytotoxic potency in the human cell lines A549 (non-small cell lung cancer), CH1/PA-1 (ovarian teratocarcinoma), and SW480 (colon carcinoma).