Quantitative HPLC-MS/MS determination of Nuc, the active metabolite of remdesivir, and its pharmacokinetics in rat
Ping Du, Guoyong Wang, Yang Song, Pengfei Li, Lihong Liu
Topics & Concepts
ChromatographyProtein precipitationPharmacokineticsChemistryActive metaboliteReproducibilityMetaboliteBioanalysisCoronavirus disease 2019 (COVID-19)High-performance liquid chromatographyTherapeutic drug monitoringSample preparationProdrugPharmacologyMedicinePathologyInfectious disease (medical specialty)DiseaseBiochemistryCOVID-19 Clinical Research StudiesAntibiotics Pharmacokinetics and EfficacyPARP inhibition in cancer therapy