Deletion of the A137R Gene from the Pandemic Strain of African Swine Fever Virus Attenuates the Strain and Offers Protection against the Virulent Pandemic Virus
Douglas P. Gladue, Elizabeth Ramírez-Medina, Elizabeth A. Vuono, Ediane Silva, Ayushi Rai, Sarah Pruitt, Nallely Espinoza, Lauro Velázquez-Salinas, Manuel V. Borca
Abstract
), demonstrating its potential as a vaccine candidate. Therefore, ASFV-G-ΔA137R is a novel experimental ASF vaccine protecting pigs from the epidemiologically relevant ASFV Georgia isolate.
Topics & Concepts
African swine fever virusVirulenceBiologyVirologyVirusAttenuated vaccinePandemicGeneDiseaseMedicineInfectious disease (medical specialty)GeneticsCoronavirus disease 2019 (COVID-19)PathologyAnimal Disease Management and EpidemiologyViral Infections and Immunology ResearchVector-Borne Animal Diseases