The microbiome of lung cancer tissue and its association with pathological and clinical parameters.
Ock‐Hwa Kim, Bo-Yun Choi, Dong Kwan Kim, Na Hyun Kim, Jin Kyung Rho, Woo Jun Sul, Sei Won Lee
Abstract
was the most predominant genus in the NSCLC tissues of patients with recurrence. The pathways related to the tricarboxylic acid cycle and L-glutamate and L-glutamine biosynthesis were predominant in adenocarcinoma, whereas those related to purine and pyrimidine nucleotide degradation and formaldehyde assimilation were predominant in squamous cell carcinoma. Our findings suggest that the altered lung cancer microbial composition might be associated with cancer initiation and/or progression.
Topics & Concepts
Lung cancerBiologyMicrobiomeAdenocarcinomaCancerPathologyCarcinogenesisCancer researchMedicineGeneticsGut microbiota and healthCancer Research and TreatmentsMicrobial Community Ecology and Physiology