Recent Advances in the Synthesis of Quinolines: A Focus on Oxidative Annulation Strategies
Mao-Lin Liao, Peng-Peng Liu, Jiacheng Yang, Ping-Gui Li, Liang‐Hua Zou
Abstract
Quinoline, a heterocyclic scaffold of paramount importance in medicinal and industrial chemistry, has garnered significant attention due to its versatile applications. Traditional synthetic methods, dating back over a century, have evolved into innovative strategies leveraging catalytic C–H bond activation, transition-metal-free protocols, and photo-induced oxidative cyclization. Recent advancements highlight the synergistic roles of catalysts, oxidants, and solvents in enhancing molecular reactivity and reaction efficiency. This review systematically summarizes state-of-the-art oxidative annulation techniques for quinoline synthesis, emphasizing mechanistic insights and practical applications.