Impact of Liposomal Spherical Nucleic Acid Structure on Immunotherapeutic Function
Cassandra E. Callmann, Caroline D. Kusmierz, Jasper W. Dittmar, Leah Broger, Chad A. Mirkin
Abstract
. This difference is further amplified when using lysates from oxidized Py8119 cells as a more potent antigen source, revealing synergy between the lysate preparation method and liposome composition in synthesizing immunotherapeutic L-SNAs. Together, this work shows that the biological properties and immunomodulatory activity of L-SNAs can be modulated by exchanging liposome components, providing another handle for the rational design of nanoscale immunotherapeutics.
Topics & Concepts
LiposomeDipalmitoylphosphatidylcholinePhosphatidylcholineIn vivoChemistryBiophysicsIn vitroOligonucleotideNucleic acidMolecular biologyBiochemistryPhospholipidBiologyDNAMembraneBiotechnologyRNA Interference and Gene DeliveryImmunotherapy and Immune ResponsesAdvanced biosensing and bioanalysis techniques