Antimyeloma Potential of Caffeic Acid Phenethyl Ester and Its Analogues through Sp1 Mediated Downregulation of IKZF1-IRF4-MYC Axis
Alli Murugesan, Grégoire Lassalle-Claux, Lauren Hogan, Elise Vaillancourt, Ayyoub Selka, Katie Luiker, Min Ji Kim, Mohamed Touaibia, Tony Reiman
Abstract
) analogues to target Ikaros (IKZF1)/IRF4 addiction, the so-called Achilles heel of myeloma, for better treatment outcomes.
Topics & Concepts
Caffeic acid phenethyl esterDownregulation and upregulationChemistryTranscription factorCancer researchCarfilzomibPharmacologyCaffeic acidBortezomibMultiple myelomaBiochemistryMedicineImmunologyAntioxidantGeneToxin Mechanisms and ImmunotoxinsInsect and Pesticide ResearchResearch on Leishmaniasis Studies