Sodium channel slow inactivation normalizes firing in axons with uneven conductance distributions
Yunliang Zang, Eve Marder, Shimon Marom
Abstract
channel slow inactivation. This "normalization" effect depends on relations between the kinetics of slow inactivation and the firing frequency. Consequently, neurons with characteristically different firing frequencies will need to implement different sets of channel properties to achieve resilience. The results of this study demonstrate the importance of the intrinsic biophysical properties of ion channels in normalizing axonal function.
Topics & Concepts
BiologyConductanceSodium channelBiophysicsChannel (broadcasting)SodiumNeuroscienceCell biologyPhysicsMaterials scienceComputer scienceMetallurgyCondensed matter physicsComputer networkNeuroscience and Neural EngineeringNeuroscience and Neuropharmacology ResearchAdvanced Memory and Neural Computing