Pseudogene-mediated DNA demethylation leads to oncogene activation
Junsu Kwon, Yanjing V. Liu, Chong Gao, Mahmoud A. Bassal, Adrianna I. Jones, Junyu Yang, Zhiyuan Chen, Ying Li, Henry Yang, Leilei Chen, Annalisa Di Ruscio, Yvonne Tay, Li Chai, Daniel G. Tenen
Abstract
pseudogene 5 hypomethylates this region through interaction with DNMT1, resulting in SALL4 up-regulation. Intriguingly, pseudogene 5 is significantly up-regulated in a hepatitis B virus model before SALL4 induction, and both are increased in patients with HBV-HCC. Our results suggest that pseudogene-mediated demethylation represents a novel mechanism of oncogene activation in cancer.
Topics & Concepts
PseudogeneOncogeneDNA methylationDNA demethylationDemethylationDNABiologyDNMT1GeneticsEpigeneticsMethylationComputational biologyCancer researchGeneMethyltransferaseGenomeGene expressionCell cycleEpigenetics and DNA MethylationCancer-related gene regulationRNA modifications and cancer