Efficient enzyme-activated therapy based on the different locations of protein and prodrug in nanoMOFs
Fan Wang, Jian Yang, Yongsheng Li, Qixin Zhuang, Jinlou Gu
Abstract
, while the IAA prodrug alone is non-toxic even at high concentrations. Thus, hierarchically porous MOFs might offer a promising platform for EAPT with a highly consistent spatiotemporal distribution of enzymes and prodrugs in target tissues.
Topics & Concepts
ProdrugEnzymeMaterials scienceAdeptCancer therapyCombinatorial chemistryNanotechnologyBiochemistryChemistryCancerMedicineInternal medicineMetal-Organic Frameworks: Synthesis and ApplicationsNanoplatforms for cancer theranosticsAdvanced Nanomaterials in Catalysis