Design, Synthesis and Cytotoxic Activity of 1,2,4-Thiadiazole Linked 1,3,4-Thiadiazole-Carbazole Derivatives
Eeduri Ramya Devi, Reddymasu Sreenivasulu, Mandava Venkata Basaveswara Rao, Koya Prabhakara Rao, R. Venkata Nadh, M. Sireesha
Abstract
A number of new 1,2,4-thiadiazole linked 1,3,4-thiadiazole-carbazole derivatives has been designed, synthesized and evaluated for cytotoxic activity against four cancer cell lines such as MCF-7 (breast cancer), Colo-205 (colon carcinoma), A549 (lung cancer), and A2780 (ovarian carcinoma) by using MTT assay and etoposide as a reference. According to the preliminary screening, most of the tested compounds have exhibited significant cytotoxicity against four cancer cell lines. One of the compounds is determined to be potent against all tested cell lines.
Topics & Concepts
ChemistryCytotoxicityEtoposideCytotoxic T cellCarbazoleMTT assayCancer cell linesCell cultureLung cancerStereochemistryCarcinoma CellOvarian cancerCombinatorial chemistryCancerCancer researchCancer cellCellIn vitroOncologyBiochemistryOrganic chemistryInternal medicineChemotherapyBiologyGeneticsMedicineSynthesis and biological activitySynthesis and Biological EvaluationClick Chemistry and Applications