Ru(II)-Catalyzed C–H Activation/[4+2] Annulation of Sulfoxonium Ylide with Maleimide: Access to Fused Benzo[<i>e</i>]isoindole-1,3,5-trione
Dattatraya H. Dethe, Vimlesh Kumar, Rahul Das
Abstract
A ruthenium-catalyzed C–H activation and a concomitant [4+2] annulation of sulfoxonium ylide with maleimide have been demonstrated. This tandem reaction results in the formation of fused benzo[ e ]isoindole-1,3,5-trione. The method employs mild conditions and is free of metal oxidants. The reaction pathway predominantly involves protodemetalation over β-hydride elimination due to the lack of syn β-hydrogens.
Topics & Concepts
AnnulationMaleimideChemistryIsoindoleYlideCatalysisRutheniumTandemMedicinal chemistryPolymer chemistryOrganic chemistryComposite materialMaterials scienceCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsOxidative Organic Chemistry Reactions