BitterDB database analysis plus cell stiffness screening identify flufenamic acid as the most potent TAS2R14-based relaxant of airway smooth muscle cells for therapeutic bronchodilation
Kai Ni, Bo Che, Rong Gu, Chunhong Wang, Hongyang Xu, H.L. Li, Shiyan Cen, Mingzhi Luo, Linhong Deng
Abstract
FFA as a potent TAS2R14 agonist to relax ASMCs while suppressing cytokine release might be a favorite drug agent for further development of TAS2R-based novel dual functional medication for bronchodilation and anti-inflammation in asthma therapy.
Topics & Concepts
MyographBronchodilatationFlufenamic acidPharmacologyMuscle relaxationAgonistChemistryBronchodilationSalbutamolReceptorCellMedicineBronchodilatorBudesonideAsthmaInternal medicineBiochemistryVasodilationBiochemical Analysis and Sensing TechniquesOlfactory and Sensory Function StudiesAsthma and respiratory diseases