Depletion of Microglia in an <i>Ex Vivo</i> Brain Slice Culture Model of West Nile Virus Infection Leads to Increased Viral Titers and Cell Death
Sarah Stonedahl, J. Smith Leser, Penny Clarke, Kenneth L. Tyler
Abstract
brain slice culture (BSC) model to investigate the role of microglia during a WNV infection. The use of BSCs provided a system in which immune responses innate to the CNS could be studied without interference from peripheral immunity. This study will allow for a better understanding of the complex nature of microglia during viral infections and will likely impact the development of new therapeutics that target microglia.
Topics & Concepts
VirologyVirusMicrogliaImmune systemBiologyPathogenesisImmunologyWest Nile virusEx vivoViremiaIn vivoInflammationGeneticsMosquito-borne diseases and controlNeuroinflammation and Neurodegeneration MechanismsHIV Research and Treatment