Cardiac endurance training alters plasma profiles of circular RNA MBOAT2
Anna Meinecke, Saskia Mitzka, Annette Just, Sarah Cushman, Stevan D. Stojanović, Ke Xiao, Frank C. Mooren, Jan Fiedler, Thomas Thum
Abstract
In brief, we herein report a timeline of circulating circular RNA (circRNA) MBOAT2 in a cohort of marathon runners. Time-course analysis of plasmatic circRNA MBOAT2 demonstrated a significantly lowered level 24 h after the marathon. Abundancy of circRNA was correlated to physical exercise parameters highlighting the role of circRNA MBOAT2 as a valuable noncoding RNA biomarker detecting and following up cardiopulmonary adaption.
Topics & Concepts
Circular RNARNABiomarkerSanger sequencingNon-coding RNAComputational biologyIn silicoBioinformaticsBiologyDNA sequencingDNAGeneGeneticsCircular RNAs in diseasesCancer-related molecular mechanisms researchMicroRNA in disease regulation