Optimal Maturation of the SIV-Specific CD8+ T Cell Response after Primary Infection Is Associated with Natural Control of SIV: ANRS SIC Study
Caroline Passaes, Antoine Millet, Vincent Madelain, Valérie Monceaux, Annie David, Pierre Versmisse, Naya Sylla, Emma Gostick, Sian Llewellyn‐Lacey, David A. Price, Antoine Blancher, Nathalie Dereuddre‐Bosquet, Delphine Desjardins, Gianfranco Pancino, Roger Le Grand, Olivier Lambotte, Michaela Müller‐Trutwin, Christine Rouzioux, Jérémie Guedj, Véronique Avettand-Fènoël, Bruno Vaslin, Asier Sáez‐Cirión
Abstract
T cells in non-controllers fail to gain antiviral potency, feasibly as a consequence of early defects imprinted in the memory pool.
Topics & Concepts
ViremiaSimian immunodeficiency virusCytotoxic T cellCD8BiologyImmunologyMacaqueVirologyRhesus macaqueImmune systemVirusIn vitroGeneticsNeuroscienceT-cell and B-cell ImmunologyImmune Cell Function and InteractionHIV Research and Treatment