Molecular Determinants of Sulfadoxine-Pyrimethamine Resistance in Plasmodium falciparum Isolates from Central Africa between 2016 and 2021: Wide Geographic Spread of Highly Mutated <i>Pfdhfr</i> and <i>Pfdhps</i> Alleles
Xiaoxiao Wang, Xuan Zhang, Hualiang Chen, Qiaoyi Lu, Wei Ruan, Zhiping Chen
Abstract
combinations, indicating the urgent concern for SP efficacy in central Africa. These findings are alarming in central African countries where malaria is endemic, where SP was is widely used for the intermittent preventive treatment of malaria in pregnancy (IPTp) and the intermittent preventive treatment of malaria in infants below 5 years of age (IPTi), and urge enhanced molecular surveillance and responses to the threat of drug resistance.
Topics & Concepts
Plasmodium falciparumSulfadoxine/pyrimethamineHaplotypeBiologyMalariaDihydropteroate synthaseSingle-nucleotide polymorphismSulfadoxineGeneticsVirologyAlleleDrug resistancePyrimethamineGenotypeGeneImmunologyMalaria Research and ControlTrypanosoma species research and implicationsResearch on Leishmaniasis Studies