Chemoselective 1,2-Sulfonamidoazidation of Styrene via Single-Atom-Site Cobalt Catalysis
Wenxuan Xue, Jing Jia, Mingtao Wu, Li-Ming Yang, Rajenahally V. Jagadeesh, Professor Dr. M. Beller, Conghui Tang
Abstract
Precise control of chemo- and regioselectivity in intermolecular difunctionalization of alkenes remains a long-standing challenge in organic synthesis. Here, we report a heterogeneous cobalt single-atom-site catalyst that enables selective 1,2-sulfonamidoazidation of styrenes. The system features good functional group tolerance and excellent recyclability. By leveraging the characteristics of single-atom-site catalysis, this work provides a valuable platform for achieving highly selective, efficient, and sustainable styrene functionalization.
Topics & Concepts
ChemistryStyreneRegioselectivityCatalysisCobaltIntermolecular forceFunctional groupOrganic chemistryCombinatorial chemistryReaction conditionsOrganic synthesisWork (physics)ChemoselectivityHomogeneous catalysisPolymer chemistryHeterogeneous catalysisGroup (periodic table)Density functional theoryProtecting groupCopolymerCatalytic C–H Functionalization MethodsSulfur-Based Synthesis TechniquesSynthesis and Catalytic Reactions