Development of Hydrogen Sulfide-Releasing Carbonic Anhydrases IX- and XII-Selective Inhibitors with Enhanced Antihyperalgesic Action in a Rat Model of Arthritis
Alessandro Bonardi, Laura Micheli, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Paola Gratteri, Alessio Nocentini, Claudiu T. Supuran
Abstract
S donor, CAI fragment, or their co-administration.
Topics & Concepts
ChemistryArthritisIn vivoPharmacologyIn vitroHydrogen sulfidePotencyBiochemistryInternal medicineMedicineOrganic chemistryBiologyBiotechnologySulfurEnzyme function and inhibitionPhenothiazines and Benzothiazines Synthesis and ActivitiesMast cells and histamine