Microwave-assisted synthesis of ruthenium(<scp>ii</scp>) complexes containing levofloxacin-induced G2/M phase arrest by triggering DNA damage
Ruotong Liu, Chanling Yuan, Feng Yin, Jiayi Qian, Xiaoting Huang, Qiutong Chen, Shuyuan Zhou, Ying Ding, Bingbing Zhai, Wenjie Mei, Liangzhong Yao
Abstract
DNA damage. In summary, these results indicated that 2 could be developed as a potential anticancer agent in treatment of lung cancer through the induction of cell cycle arrest at G2/M phase by triggering DNA damage.
Topics & Concepts
RutheniumChemistryDNA synthesisDNA damageDNAPhase (matter)Solid-phase synthesisLevofloxacinCombinatorial chemistryStereochemistryBiochemistryCatalysisOrganic chemistryPeptideAntibioticsMetal complexes synthesis and propertiesDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniques