Electrochemical trifluoromethylation/cyclization for the synthesis of isoquinoline-1,3-diones and oxindoles
Yuanqiang Guo, Ruiguo Wang, Hongjian Song, Yuxiu Liu, Qingmin Wang
Abstract
) used in this strategy is inexpensive and easy to obtain, and the reaction can be conducted efficiently without the addition of additional redox reagents. Using this strategy, we achieved electrochemical trifluoromethylation/cyclization for the synthesis of isoquinoline-1,3-diones and oxindoles. This protocol has good functional group tolerance and a broad substrate scope.
Topics & Concepts
TrifluoromethylationIsoquinolineElectrochemistryTrifluoromethylChemistryCombinatorial chemistryRadicalCathodeReduction (mathematics)Organic chemistryElectrodePhysical chemistryMathematicsAlkylGeometryFluorine in Organic ChemistryRadical Photochemical ReactionsCatalytic C–H Functionalization Methods