Prematurity blunts the insulin- and amino acid-induced stimulation of translation initiation and protein synthesis in skeletal muscle of neonatal pigs
Marko Rudar, Jane Naberhuis, Agus Suryawan, Hanh V. Nguyen, Barbara J. Stoll, Candace C. Style, Mariatu A. Verla, Oluyinka O. Olutoye, Douglas G. Burrin, Marta L. Fiorotto, Teresa A. Davis
Abstract
Extrauterine growth faltering is a major complication of premature birth, but the underlying cause is poorly understood. Our results demonstrate that preterm birth blunts both the insulin-and amino acid-induced activation of mTORC1-dependent translation initiation and protein synthesis in skeletal muscle, thereby limiting the anabolic response to feeding. This anabolic resistance likely contributes to the reduced accretion of lean mass and extrauterine growth restriction of premature infants.
Topics & Concepts
mTORC1AnabolismEndocrinologyInternal medicinePI3K/AKT/mTOR pathwaySkeletal muscleAmino acidInsulinBiologyInsulin resistanceProtein biosynthesisChemistryMedicineSignal transductionBiochemistryPancreatic function and diabetesMuscle metabolism and nutritionInfant Nutrition and Health