Structure-based discovery of novel 4-(2-fluorophenoxy)quinoline derivatives as c-Met inhibitors using isocyanide-involved multicomponent reactions
Xiang Nan, Hui‐Jing Li, Senbiao Fang, Qinying Li, Yan‐Chao Wu
Topics & Concepts
ChemistryIC50QuinolinePotencyKinaseDocking (animal)Tyrosine kinaseLinkerStereochemistryCell cultureStructure–activity relationshipCell growthIn vitroBiochemistrySignal transductionComputer scienceOrganic chemistryMedicineOperating systemGeneticsBiologyNursingChemical Synthesis and AnalysisLiver physiology and pathologyCancer therapeutics and mechanisms