<scp><i>cis</i>‐Clerodane</scp> Diterpenoids with Structural Diversity and Anti‐inflammatory Activity from <i>Tinospora crispa</i>
Jin‐Qiu You, Yi‐Nan Liu, Jun‐Su Zhou, Xinyu Sun, Chun Lei, Qing Mu, Jingya Li, Ai‐Jun Hou
Abstract
Comprehensive Summary Twelve new cis ‐clerodane diterpenoids, designated as crispinoids A—L ( 1 — 12 ), together with three known analogues ( 13 — 15 ), were isolated from Tinospora crispa . Their structures were fully assigned by comprehensive spectroscopic techniques, single‐crystal X‐ray diffraction experiments, and electronic circular dichroism (ECD) analyses. The isolated clerodanes displayed diverse heterocyclic frameworks including 6/6/6‐, 6/5/6/6‐, 6/6/5‐, 6/6‐, and 6/5/6‐fused ring systems. Some of the isolates showed ATP‐citrate lyase (ACLY) and nuclear factor kappa B (NF‐ κ B) pathway inhibition. The NF‐ κ B inhibitors further suppressed the lipopolysaccharide (LPS)‐induced inflammatory responses in RAW 264.7 cells.