Discovery of novel hybrids containing clioquinol−1-benzyl-1,2,3,6-tetrahydropyridine as multi-target-directed ligands (MTDLs) against Alzheimer's disease
Xinnan Li, Tiantian Li, Pengfei Zhang, Xinuo Li, Li Lu, Yuan Sun, Bocheng Zhang, Stephanie Allen, Lisa J. White, James B. Phillips, Zheying Zhu, Hequan Yao, Jinyi Xu
Topics & Concepts
ChemistryClioquinolAcetylcholinesteraseTacrineNeuroprotectionPharmacologyAchéIn vivoLead compoundDonepezilInhibitory postsynaptic potentialIC50RivastigmineCholinesteraseBiochemistryIn vitroNeuroscienceDementiaEnzymeInternal medicineDiseaseMedicineBiologyBiotechnologyCholinesterase and Neurodegenerative DiseasesAlzheimer's disease research and treatmentsComputational Drug Discovery Methods