Kinetic resolution of azaflavanones<i>via</i>a RuPHOX-Ru catalyzed asymmetric hydrogenation
Yue Zhu, Jiayu Zhou, Jing Li, Kai Xu, Jianxun Ye, Yufei Lu, Delong Liu, Wanbin Zhang
Abstract
The kinetic resolution of azaflavanones has been established via RuPHOX-Ru catalyzed asymmetric hydrogenation, providing chiral azaflavanones and azaflavanols in high yields with up to >20 : 1 dr and 99.7% ee.
Topics & Concepts
Kinetic resolutionChemistryCatalysisKinetic energyAsymmetric hydrogenationRutheniumResolution (logic)Medicinal chemistryEnantioselective synthesisCombinatorial chemistryOrganic chemistryPhysicsComputer scienceQuantum mechanicsArtificial intelligenceAsymmetric Hydrogenation and CatalysisCatalysis for Biomass ConversionSurface Chemistry and Catalysis